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FLASH GENE
Symbol MTA2 contributors: mct - updated : 17-06-2014
HGNC name metastasis associated 1 family, member 2
HGNC id 7411
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3069 - 668 - 1999 9929979
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BAH domain
  • a ELM2 domain
  • a SANT domain similar to the DNA binding domain of myb-related proteins
  • a GATA-like zinc-finger domain
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Mta2
    ortholog to rattus Mta2
    intraspecies paralog to MTA1
    Homologene
    FAMILY
  • NURD complex family (nucleosome remodeling deacetylase complex)
  • metastasis associated family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • may be involved in the regulation of gene expression as repressor and activator
  • regulating histone deacetylase core complex enzymatic activity
  • modulating TP53-mediated cell growth arrest and apoptosis
  • participates in the down-regulation of FSHR transcription
  • required for TIPIN-dependent Polymerase alpha binding to replicating chromatin, and this function is essential to prevent the accumulation of reversed forks
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the NuRD nucleosome remodeling deacetylase complex with HDAC1, HDAC2, histone binding proteins and MBD3
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacting with HDAC7, TP53, MINT and MBD3
  • potent corepressor of FSHR transcription, because it can recruit histone deacetylase-1 onto the FSHR promoter and participates in the down-regulation of FSHR expression upon FSH treatment
  • SETD6 associated with HDAC1 and MTA2
  • is a novel TIPIN binding partner and mediator of its function
  • cell & other
    REGULATION
    induced by directly by testosterone or indirectly by FSH, and is exclusively expressed in Sertoli cells
    Other association of MTA1L1 with the core histone deacetylase complex mediated by MBD3
    post-translational regulation of MTA2 by the way of EP300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    increasing metastatic potential of certain carcinomas
    tumoral     --over  
    in several solid tumors and associated with tumor cells migration and invasion
    tumoral     --over  
    tight correlation between the MTA2 expression level and hepatocellular carcinoma size and differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • cytoplasmic CTNND1, cytoplasmic ZBTB33, and nuclear MTA2 expression correlated directly with histological type and Masaoka stage and may thus be used as potential biomarkers to predict biological behavior of thymoma
  • Therapy target
    ANIMAL & CELL MODELS