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FLASH GENE
Symbol POLD3 contributors: mct/npt - updated : 23-01-2019
HGNC name polymerase (DNA-directed), delta 3, accessory subunit
HGNC id 20932
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3430 51.3 466 - Masuda (2007)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich domain
  • a bipartite nuclear localization signal (NLS)
  • a highly conserved region between AAs 384 and 399 in the C-terminus phosphorylated, most probably by Protein kinase CK2, and another region, most probably located within the PCNA interacting domain in its extreme C-terminus, regulates its interaction with PCNA (Lemmens 2008)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to yeast S.pombe Cdc27
    Homologene
    FAMILY
  • polymerase delta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polymerase (DNA directed) delta 3, accessory subunit
  • mainly mediate polymerase interaction with PCNA, an auxiliary factor that greatly enhances DNA polymerase delta processivity on primed DNA templates (Lemmens 2008)
  • concurrent phosphorylation events may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle (Lemmens 2008)
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text nuclear genome
    PATHWAY
    metabolism
    signaling
    a component
  • also complexing with DNA ligase 1
  • heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa, and 12 kDa
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to PCNA (POLD3 plays a crucial role in the efficient recycling of PCNA during dissociation-association cycles of pol delta) (Masuda 2007)
  • negatively regulates error-prone translesion synthesis that is dependent on POLD3, the accessory subunit of the replicative DNA polymerase Pol delta
  • mitotic DNA synthesis, termed MiDAS, requires the MUS81-EME1 endonuclease and a non-catalytic subunit of the Pol-delta complex, POLD3
  • cell & other
    REGULATION
    Other modified by ubiquitin and SUMO3 (Liu 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to colorectal cancer
    Variant & Polymorphism
  • rs3824999, intronic to POLD3 influences colorectal cancer risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS