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FLASH GENE
Symbol ACTR1B contributors: mct - updated : 30-08-2008
HGNC name ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
HGNC id 168
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2054 42 376 - Hillier (2005)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousnerve   highly
Reproductivefemale systemuteruscervix highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast actin related protein 1
intraspecies paralog to ACTR1A
Homologene
FAMILY
  • actin family
  • ARP1 subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • regulator of cytoplasmic dynein-mediated functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the large macromolecular complex, dynactin, actin-like microfilament backbone, required for the cytoplasmic dynein-driven movement of organelles along microtubules
  • involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCTN1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS