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FLASH GENE
Symbol IL16 contributors: mct/ - updated : 21-06-2006
HGNC name interleukin 16 (lymphocyte chemoattractant factor)
HGNC id 5980
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 6077 66.5 631 - -
18 - 8065 141.6 1332 - -
19 - 8322 - 1331 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two PDZ/DHR domains
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Il16
    homolog to C.elegans F59a3.8
    Homologene
    FAMILY
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inducing the chemotactic and immunomodulatory responses of CD4+lymphocytes
  • monocyte, eosinophil and lymphocyte chemoattractant factor
  • modulating T-cell activation and replication of HIV
  • inducing T-lymphocyte expression of interleukine two receptor
  • involvement of the IL16 precursor molecules in myosin-based contractile processes, most likely in cell motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    cell to cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD4 receptor
  • cell & other
    REGULATION
    induced by GABP alpha and beta
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS