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FLASH GENE
Symbol MAP2K6 contributors: SGE/npt - updated : 14-09-2018
HGNC name mitogen-activated protein kinase kinase 6
HGNC id 6846
RNA
TRANSCRIPTS type messenger
text several alternatively spliced isoforms, with distinct tissue expression (Han)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1879 - 334 skeletal muscle, heart, liver, pancreas Inoue (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map2k6
    homolog to C.elegans R03g5.2
    intraspecies homolog to MAP2K3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine/threonine kinase, controlling cell proliferation (cell cycle arrest)
  • involved in TNFA mediated endothelial SCYA2 (MCP1) expression
  • involved in BMP4-stimulated osteocalcin synthesis, as a positive regulator in osteoblasts
  • activating PRKMK8 and p38 kinase (MAPK) and required for ABL1 induced apoptosis
  • downregulates NADPH oxidase activity by enhancing Rac-GTPase activity (Harraz 2007)
  • with MAP3K7, constitute the p38 signalling pathway to participate to Osteoclasts differentiation by TNFSF11 through p65 phosphorylation and NFATC1 induction (Huang 2006)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38-dependent mRNA stabilization of 42 AU rich genes, some involved in macrophage activation
  • inducing SOCS3
  • stress activated kinase MAP2K6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
  • cell & other
    REGULATION
    activated by UV, anisomycin and os miotic stock
    phosphorylation
    TNFA
    Other phosphorylated by MAP3K5 (Sturchler 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS