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FLASH GENE
Symbol SRPK2 contributors: mct/npt/pgu - updated : 13-01-2010
HGNC name SFRS protein kinase 2
HGNC id 11306
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3671 - 699 - 2009 19592491
15 - 3737 77.5 688 - 2009 19592491
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   predominantly Homo sapiens
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervouscentral    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES acid ,basic
STRUCTURE
motifs/domains
  • N-terminal domain cleaved by caspases, translocates into the nucleus, where it promotes chromatin condensation and apoptotic cell death
  • conserved serine/threonine kinase domains
  • a proline-rich domain
  • a basic region which may be a nuclear localization signal (NLS)
  • an acidic domain
  • HOMOLOGY
    interspecies homolog to murine Srpk2
    intraspecies homolog to srpk1
    Homologene
    FAMILY
  • SRPK family of kinases
  • CMGC Ser/Thr protein kinase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • both SRPK1 and SRPK2 are primarily localized in the cytoplasm despite having putative nuclear localization signals
  • basic FUNCTION
  • splicing factor, modulating the affinity between RS domain containing proteins and regulating the cellular distribution of their substrates
  • playing a role in the spliceosome assembly
  • may play an important role in linking signaling to RNA metabolism in higher eukaryotic cells
  • controling localization of splicing factors
  • implicated in spliceosome assembly and catalytic activation
  • playing a role in splicing
  • protein kinase specific for the serine/arginine (SR) family of splicing factors, triggering cell cycle progression in neurons and inducing apoptosis through regulation of nuclear cyclin D1
  • its phosphorylation is necessary for phosphatidylinositol 3-kinase/Akt mediating the cell cycle and cell death machinery in the nervous system
  • phosphorylate serine/arginine (SR) domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing
  • involved in the molecular chaperone system that has been implicated in numerous signal transduction pathways and provide mechanistic insights into complex regulation of SR protein phosphorylation and alternative splicing in response to developmental cues and cellular signaling
  • phosphorylate SR domain-containing proteins in the nuclear speckles and mediate the pre-mRNA splicing
  • in addition to phosphorylating SR proteins and regulating pre-mRNA splicing, SRPK1 and SRPK2 also play an important role in cell proliferation and apoptosis
  • active SRPK2 can trigger apoptosis which depends on its kinase activity and is also a substrate of caspases whose action releases an N-terminal fragment from the kinase, involved in apoptotic cell death
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the U4/U6-U5 tri-snRNP
  • binds and phosphorylates acinus (ACIN1), an SR protein essential for RNA splicing, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not A2 up-regulation
  • binds YWHAQ (Akt phosphorylation provokes SRPK2 nuclear translocation that is blocked by YWHAQ)
  • cell & other
    REGULATION
    repressed by YWHAQ (antagonizes the SRPK2 stimulatory effect on cyclin D1 expression, resulting in blockage of neuronal apoptosis elicited by SRPK2)
    Other regulated by SAFB proteins (regulators of SRPK1 and SRPK2 activity underlining the importance of the assembly of transient intranuclear complexes in cellular regulation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    with ACIN1 in some human acute myelogenous leukemia patients and correlate with elevated cyclin A1 expression levels
    constitutional       gain of function
    up-regulates HIV expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    inhibitors of SRPK2 and perhaps of functionally related kinases, such as SRPK1, could be useful antiviral agents
    ANIMAL & CELL MODELS