basic FUNCTION
| regulator of circadian rhythms and in restting a peripheral vascular clock (acting in connection with ARNTL as a transcriptional activator in the circadian pacemaker) |
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activating the transcription from the e-box element |
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required with BMAL1 for both circadian transcription and chromatin modification |
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acting as a histone acetyltransferase |
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CLOCK/ARNTL regulates CCRN4L (nocturnin) transcription through binding to the E-box of nocturnin promoter |
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plays important roles in regulating the circadian rhythms in photoreceptor cells |
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overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators |
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CLOCK/ARNTL regulates human nocturnin transcription through binding to the E-box of nocturnin promoter |
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with ARNTL, are involved in the neuronal differentiation of adult neural stem/progenitor cells which may extend our understanding of various neurological/psychological disorders linked to adult neurogenesis and circadian rhythm |
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possible involvement of CLOCK in susceptibility to n attention-deficit hyperactivity disorder (ADHD) |
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drives the transcriptional activation of GYS2 via two tandemly located E-boxes |
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regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of GYS2 |
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CLOCK and ARNTL are critical modulators of molecular, cellular, and functional parameters of skeletal muscle |
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CLOCK is a modulator of the key regulator of immune response, transcription factor NFKB1 |
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CLOCK increases NFKB1–mediated transcriptional activation of responsive promoters independent of its circadian partner ARNTL |
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ARNTL and CLOCK contribute to chromatoid body (CB) assembly and physiology |
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CLOCK, MTTP, and NOCT are involved in the circadian regulation of intestinal lipid absorption |
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CLOCK and ARNTL drives rhythmic gene expression and regulate biological functions under circadian control |
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CLOCK-dependent direct transactivation through multiple E-boxes and indirect regulations polyphonically orchestrate dynamic circadian outputs |
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plays a key role in maintaining circadian rhythms and activation of downstream elements |
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plays an important role in fertility and the CLOCK knockdown leads to reduction in reproduction and increased miscarriage risk |