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FLASH GENE
Symbol ABCB5 contributors: mct - updated : 11-10-2013
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 5
HGNC id 46
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 5401 - 1257 prostate, testis 2012 2230600
  • has ATPase activity that is sensitive to docetaxel
  • 19 - 4375 - 812 highly expressed in human melanoma cells 2012 2230600
  • ABCB5beta, with a transmembrane domain and a nucleotide-binding domain
  • 6 - 1724 - 126 - 2012 2230600
    6 - 2247 - 131 - 2012 2230600
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
     male systemprostate    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two ATP binding and two transmembrane (2TM) domains (2 x 6 segments)
  • an ABC transmembrane type-1 domain
  • two transmembrane and two nucleotide-binding domains
  • HOMOLOGY
    Homologene
    FAMILY ATP binding cassette superfamily, subfamily B (MDR/TAP)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin
  • functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells
  • responsible for the resistance to doxorubicin of a subset of malignant melanomas
  • full-sized ABC transporter that confers anticancer drug resistance
  • acts as an energy-dependent drug efflux transporter and marks tumour cells of a putative cancer stem cell (CSC) compartment
  • its expression is closely linked to tumorigenicity and progression of diverse human malignancies, including melanoma, and is functionally required for tumor growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanomas
    tumoral     --over  
    significantly associated with tumour progression and recurrence of the oral squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS