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FLASH GENE
Symbol NBAS contributors: mct/npt - updated : 21-08-2015
HGNC name neuroblastoma amplified sequence
HGNC id 15625
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
52 - 7299 268 2371 - Scott (2003)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 pancreas    
 thyroid   highly
Lymphoid/Immunelymph node   highly
nervousbraindiencephalon   
Reproductivefemale systembreastmammary gland highly
 male systemtestis   
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text heart, kidney, lung, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal sequence containing a leucine zipper motif
  • three putative transmembrane helices
  • an endoplasmic reticulum signal sequence
  • two peroxisomal targeting signals
  • two clusters of nuclear localization signals
  • one within the N-terminal sequence
  • the other within the common C-terminal sequence half
  • HOMOLOGY
    Homologene
    FAMILY
  • neuroblastoma-amplified protein family
  • CATEGORY RNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • structural constituent of ribosome
  • DHX34 and NBAS act in concert with core nonsense-mediated mRNA decay (NMD) factors to co-regulate a large number of endogenous RNA targets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ILFS2 , SOPH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in neuroblastoma, low stage in MYCN-amplified tumours
    tumoral   amplification    
    MYCN amplicon, coamplified with N-Myc
    tumoral   translocation    
    fused with ELMO1 in translocation, t(2;7)(p24.3;p14.2), in a case of acute myeloid leukemia transformed from myelodysplastic syndrome (Fujita 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS