protein
| associating with BTG1 (potential tumor suppressor), driving the formation of CAF1 complex with NOTs proteins |
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binds to PYCARD and NLRP2, thereby blocking formation of cryopyrin and NLRP2-containing inflammasomes, activation of caspase-1, and subsequent processing and secretion of bioactive interleukin-1beta |
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interacting with BTG2 |
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TOB1 binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex |
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anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes |
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CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module |
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BTG2 bridges PABPC1 RNA-binding domains and CNOT7, CNOT8 deadenylase to control cell proliferation |
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BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay |