basic FUNCTION
| Spemann organizer binding and inactivating BMP4 and other TGFB family members |
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involved in the joint formation and in skeletogenesis |
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playing a role in creating morphogenetic gradients |
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required for induction of the hair follicles growth phase in postnatal skin (through the modulation of BMP4) |
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soluble BMP antagonists, regulating the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition |
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bone morphogenetic protein antagonist promoting skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways (Sharov 2009) |
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may contribute to the myelofibrotic process characterized by bone marrow stromal reaction including collagen fibrosis, osteosclerosis, and angiogenesis (Andrieux 2007) |
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NOG and GREM1 cooperate potentialy to maintain a BMP signaling-free zone that is a crucial prerequisite for Hh-mediated sclerotome induction |
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glycosylated-secreted protein known so far for its inhibitory effects on bone morphogenetic protein (BMP) signaling by sequestering the BMP ligand |
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novel role for noggin as an inducer of adipogenesis |
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regulates both osteoblast and adipocyte differentiation of mesenchymal stemcell (MSC) and, hence, is a master regulator of MSC plasticity |
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BMP inhibitor, providing metastatic breast cancer cells with the ability to colonize the bone |
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NOG and GREM1 having potential role in normal tissue homeostasis as well as in malignancies |