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FLASH GENE
Symbol NOG contributors: mct/npt - updated : 30-01-2015
HGNC name noggin
HGNC id 7866
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1892 25 232 - 2009 19700758
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrainhindbraincerebellum  
 brainforebraincerebral cortex  
Reproductivefemale systemuterus   
 female systemplacenta   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
Nervoustufted cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text developing bone, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to rattus LOC363665
homolog to murine Nog
Homologene
FAMILY
  • noggin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • Spemann organizer binding and inactivating BMP4 and other TGFB family members
  • involved in the joint formation and in skeletogenesis
  • playing a role in creating morphogenetic gradients
  • required for induction of the hair follicles growth phase in postnatal skin (through the modulation of BMP4)
  • soluble BMP antagonists, regulating the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition
  • bone morphogenetic protein antagonist promoting skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways (Sharov 2009)
  • may contribute to the myelofibrotic process characterized by bone marrow stromal reaction including collagen fibrosis, osteosclerosis, and angiogenesis (Andrieux 2007)
  • NOG and GREM1 cooperate potentialy to maintain a BMP signaling-free zone that is a crucial prerequisite for Hh-mediated sclerotome induction
  • glycosylated-secreted protein known so far for its inhibitory effects on bone morphogenetic protein (BMP) signaling by sequestering the BMP ligand
  • novel role for noggin as an inducer of adipogenesis
  • regulates both osteoblast and adipocyte differentiation of mesenchymal stemcell (MSC) and, hence, is a master regulator of MSC plasticity
  • BMP inhibitor, providing metastatic breast cancer cells with the ability to colonize the bone
  • NOG and GREM1 having potential role in normal tissue homeostasis as well as in malignancies
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , nervous system
    text embryogenesis, morphogenesis and neurogenesis, bone development and maintenance, dorsal ventral polarity
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • homodimer disulfide-linked
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP4 (inactivation of BMP4)
  • TGFB family of signaling proteins
  • harmonious interactions between NOGGIN and BMP4 in periodontal ligament-forming cells, which show higher cell proliferation than neighboring cells, might be important for proper periodontium development (Kim 2007)
  • RNA-binding protein FXR2 specifically regulates dentate gyrus (DG) of the hippocampus neurogenesis by reducing the stability of NOG mRNA
  • apoptotic effect of BMP2 is dependent on cell maturation state, inducing apoptosis in committed osteoblasts through SMAD and TAB/TAK1 signaling, and is regulated by NOG
  • BMP4 antagonist NOG attenuates valve interstitial cells (VICs) activation and biomineralization
  • FST interacts with NOG in the development of the axial skeleton
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SYM1 , SYNS1 , SABT , BDB2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BMP6, NOG and SOST could be used in combination as a prognostic indicator in cancer progression
  • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    potential of noggin as a therapeutic target to control obesity
    ANIMAL & CELL MODELS
  • noggin knockout mice
  • required for mouse forebrain development
  • Obese mice with elevated noggin have reduced bone mineral density