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FLASH GENE
Symbol CER1 contributors: mct - updated : 10-07-2014
HGNC name cerberus 1 homolog, cysteine knot superfamily (Xenopus laevis)
HGNC id 1862
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1206 - 267 - 1999 10049596
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion
at STAGE
Text stem (ES) cells in the undifferentiated state and in the early endodermal lineage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine conserved cysteines and C-terminal cysteine knot-like domain (CTCK)
HOMOLOGY
interspecies homolog to Xenopus laevis
Homologene
FAMILY
  • member of cysteine knot superfamily
  • DAN domain (DAND) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • secreted cytokine, potentially involved in anterior neural induction and somite formation during mouse development
  • bone morphogenetic protein antagonist
  • inhibit NODAL signaling through ACVR1B (ALK4) or ACVR1C (ALK7) to SMAD2 or SMAD3
  • Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo (pMID: 19247954)
  • HHEX and CER1 mediate the SOX17 pathway for cardiac mesoderm formation in embryonic stem cells
  • profoundly suppresses migration, invasion, and colony forming ability of Nodal expressing and Nodal supplemented breast cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • potentially involved in ? anteroposterior and left-right (L/R) asymetry
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bone morphogenetic proteins
  • common target of WNT and NODAL signaling pathways in embryonic stem cells
  • transient inhibition of NODAL by CER1 induces Brahma-associated factor 60c (SMARCD3)
  • APLNR controls a regulatory CER1-SMARCD3 pathway in pluripotent stem cell cardiomyogenesis (pMID: 23787002)
  • LHX2 attenuates BMP and WNT signaling by promoting expression of the BMP and WNT antagonist CER1, to inhibit non-neural differentiation
  • binds NODAL with high affinity and specificity, blocks binding of NODAL to its signaling partners, and inhibits NODAL signaling
  • cell & other
    REGULATION
    induced by HH
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL9P
    Susceptibility to osteoporosis
    Variant & Polymorphism other CER1 variations seem to play a significant role in the determination of osteoporosis and a potential predictive role, in postmenopausal osteoporotic women
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    asymetriclly expressed in mice