Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BATF contributors: mct - updated : 29-05-2018
HGNC name basic leucine zipper transcription factor, ATF-like
HGNC id 958
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 953 14 125 - 2016 26970726
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 tonsils   predominantly
Respiratorylung   moderately
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunelymphocyte
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion blood, lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) domain
  • conjugated PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • Activator protein-1 family /ATF superfamily
  • bZIP family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a negative regulator of AP-1 mediated transcription by binding to Jun proteins
  • BATF is a central regulator of the Th9 phenotype and contributes to the development of allergic inflammation
  • critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text blocking transformation by RAS and FOSx
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimers with JUN, JUNB and JUND
  • INTERACTION
    DNA binding as an heterodimer to the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP responsive region (CRE) (consensus: 5'- GTGACGT[AC][AG]-3')
    RNA
    small molecule
    protein
  • proteins of the JUN family
  • IFI35
  • role of BATF in CD4(+) T cell subsets and in CD8(+) T cells
  • BATF/JUNB and BATF/JUN complexes play important roles in osteoarthritic cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes
  • cell & other
    REGULATION
    induced by EB virus in B cells
    inhibited by HTLV1 in T cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    retinoic acid (RA) signaling and BATF productions are activated in IgAN (Immunoglobulin A Nephropathy) patients compared with controls
    constitutional     --over  
    in non-steroid-treated asthmatic children
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    novel target for antiasthma interventions
    ANIMAL & CELL MODELS