Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HUS1 contributors: mct/npt/pgu - updated : 28-01-2009
HGNC name HUS1 checkpoint homolog (S. pombe)
HGNC id 5309
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2143 31.7 280 - 2008 18794804
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to yeast S.pombe Hos1
homolog to murine Hus1
Homologene
FAMILY
  • HUS1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in cell cycle G2 checkpoint control
  • involved in DNA damage checkpoint regulation, which is required for the maintenance of genomic stability
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text DNA damage checkpoint
    PATHWAY
    metabolism
    signaling
    a component
  • forming DNA damage-responsive protein complex with RAD1 and RAD9A, heterotrimeric complex (Rad9A-Rad1-Hus1 cell cycle checkpoint complex plays a key role in the DNA damage response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with itself and the C terminus of RAD1
  • interacting with TDG
  • interacting with COPS5 (mediates protein degradation of the Rad9A-Rad1-Hus1 checkpoint complex)
  • DNA2 shows partial redundancy for the replication checkpoint with checkpoint initiators RAD9-RAD1-HUS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    sensitizes cells to etoposide-induced apoptosis not only by inducing BCL2L11 and BBC3 expressions but also by releasing RAD9A into the cytosol to augment mitochondrial apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene prognostic markers in epithelial ovarian tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS