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FLASH GENE
Symbol ELF5 contributors: mct/ - updated : 28-06-2022
HGNC name E74-like factor 5 (ets domain transcription factor)
HGNC id 3320
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2466 31.1 265 - 2021 34146197
7 - 2317 30 255 - 2021 34146197
5 - 2032 - 160 - 2021 34146197
5 - 2146 - 187 - 2021 34146197
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary gland   highly
 stomach   highly
Reproductivefemale systembreast   
 male systemprostate   
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   highly
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Epithelialsecretoryglandular  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text in the placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells (Hemberger 2010)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a negative N regulatory domain at the N-terminus
  • consensus motif with a GGA core and an AT-rich 5'- and 3'-flanking sequences
  • HOMOLOGY
    intraspecies homolog to ELF3
    Homologene
    FAMILY
  • ETS family
  • ESE(epithelium-specific Ets) subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • putative regulator of epithelial cell differentiation, possibly involved in humorigenesis
  • potential regulator of target genes
  • functions as a gatekeeper, downstream of initial lineage determination, to reinforce commitment to the trophoblast lineage or to abort this pathway in cells of the embryonic lineage (Hemberger 2010)
  • transcription factor ELF5 is likely necessary for correct trophoblast development
  • ELF5 and kRT77 are induced earlier during epidermal development
  • ELF5-mediated AR activation regulates prostate cancer progression
  • basic transcription factor that plays a key role in breast tissue and gland development (
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ELF5 is a principal cell lineage specific transcription factor in the kidney that contributes to AQP2 and AVPR2 gene expression
  • ELF5 inhibits likely migration and invasion of breast cancer cells by regulating CD24 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    hypermethylated and largely repressed in embryonic stem cells and derived trophoblast cell lines (Hemberger 2010)
    tumoral     --low  
    in ovarian cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    ELF5 inhibit breast cancer from a new perspective and provides further theoretical support for the treatment and prevention of breast cancer
    cancerreproductiveovary
    could provide a new approach to gene treatment of ovarian carcinoma
    ANIMAL & CELL MODELS