Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EFNA2 contributors: mct - updated : 04-02-2012
HGNC name ephrin-A2
HGNC id 3222
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text ligand expressed in brain and intestines
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • a receptor-binding region
  • a spacer region
  • a hydrophobic region
  • HOMOLOGY
    Homologene
    FAMILY ephrin family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a glycosylphosphatidylinositol linkage
    basic FUNCTION
  • playing a key role in controlling cell movements in many tissues and at multiple stages of patterning
  • EFNA2 and EPHA7 as negative regulators of progenitor cell proliferation
  • EFNA2, EFNA3, EFNA5, and neural activity act together to control patterning of eye-specific retinogeniculate layers
  • playing a specific role in postnatal neurogenesis
  • bidirectional EFNA2-EPHA2 signaling regulates bone remodeling at the initiation phase
  • EFNA1 and EFNA2, but not the EFNA3, EFNA4, EFNA5 cluster, regulate the members of the ubiquitin-associated proteolysis genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5
  • EFNA2-EPHA2 interaction facilitates the initiation phase of bone remodeling by enhancing osteoclast differentiation and suppressing osteoblast differentiation
  • cell & other
    REGULATION
    induced by rapidly induced by receptor activator of NF-kappaB ligand in osteoclast precursors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Efna2(-/-) mice have abnormal topography in the primary visual system but have normal visual and learning performance on a simple visual discrimination task