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FLASH GENE
Symbol PIK3C2G contributors: mct - updated : 21-07-2006
HGNC name phosphoinositide-3-kinase, class 2, gamma polypeptide
HGNC id 8973
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineparathyroid   highly
Reproductivefemale systembreast   
 male systemprostate   
 male systemtestis  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Ras-binding domain three regions of homology
  • a phox (PX) domain
  • one (? or two) universal Ca2+ binding domain(s) (C2)
  • a PI3K/PI4K domain
  • a lipid kinase catalytic domain
  • a C-terminal C2 domain, a characteristic of class II PI3-kinases, acting as calcium-dependent phospholipid binding motifs
  • HOMOLOGY
    Homologene
    FAMILY PI3/PI4-kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP significant association for SNPs 2 and 4 to type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS