basic FUNCTION
| DNA helicase with an intrinsic DNA strand-annealing function residing in a separate domain |
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may promote regression of stalled replication forks to facilitate the bypass of replication-blocking lesions by template-switching |
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ATP-dependent 3'-5' DNA helicase that can promote migration of Holliday junctions |
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possesses an intrinsic DNA strand-annealing activity that is inhibited by RPA1 |
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may have an important role in DNA metabolism and may also be related to a distinct genetic disease |
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playing a role at the interface of transcription and genomic stability |
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important tumor suppressor that may act by preventing inappropriate homologous recombination events via Rad51 presynaptic filament disruption |
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might play completely separate roles in transcription and genome integrity and may only be involved in transcription |
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specifically inhibits the 3'-->5' exonuclease activity of MRE11 |
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recruited by the MRN complex to sites of DNA damage to regulate DNA repair |
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inhibits both initiation and elongation of transcription, without the helicase activity |
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promotes genome stabilization through two parallel mechanisms: by participation in homologous recombination-dependent DNA repair as a RecQ helicase and by regulating the initiation of Pol II to reduce transcription-associated replication impairment and recombination |
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may play a role in the stabilization and/or restart of stalled replication forks |
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ability of RecQL5 to regulate recombination, replication, and transcription makes it a crucial guardian of genome integrity |
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promotes genomic stability by regulating homologous recombination |
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plays a role in the maintenance of genomic stability during transcription |
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role for RECQL5 in preventing transcription-associated DSBs during replication |
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RECQL5 modulates likely and/or directly participates in base excision repair of endogenous DNA damage, thereby promoting chromosome stability in normal human cells |
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promotes chromosome stability in normal human cells by playing a nonredundant and unique role in Base excision repair (BER), specifically modulating and/or directly participating in BER-mediated repair of endogenous DNA damage |
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RECQL5 is the one human RECQ helicase expressed independently of the cell cycle, and this enzyme appears to play a specialized role in the repair of endogenous DNA damage |
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RECQL5 is essential for cell survival in the absence of WRN |
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promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing |
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RECQL5 is a general elongation factor that is important for preserving genome stability during transcription |
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controls transcript elongation and suppresses genome instability associated with transcription stress |
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RECQL5 is a critical regulator of genome stability in myeloproliferative neoplasms (MPNs) |
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is one of five human RecQ proteins and is particularly versatile in this regard, forming protein complexes with a diverse set of cellular partners in order to coordinate its helicase activity to various processes including replication, recombination and DNA repair |
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RECQL5 co-operates with WRN on synthetic stalled replication fork-like structures and stimulates its helicase activity on DNA fork duplexes |
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RECQL5 plays both co-operative and complementary roles with WRN |