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FLASH GENE
Symbol SMARCA5 contributors: mct/npt/pgu - updated : 19-10-2018
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
HGNC id 11101
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 3866 - 1052 - 2000 10655480
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Nervousbrain   highly Homo sapiens
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATPase domain containing a leucine zipper motif
  • DEAD (Asp-Glu-Ala-Asp) box helicase domain, a conserved ATPase domain that belongs to the superfamily of DEAD/H-helicases (
  • a SNF2 helicase and two SANT domains at the C terminus
  • HOMOLOGY
    interspecies homolog to Drosophila ISWI (imitation of SWI)
    homolog to yeast S.cerevisiae SWI/SNF related protein general transcriptional activator
    intraspecies paralog to SMARCA1
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • ISWI subfamily
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text colocalizing with UBTF and BAZ2A in the nucleolus
    basic FUNCTION
  • actin-dependent regulator of chromatin
  • playing a role in chromatin remodeling by mediating the association of cohesin and chromatin
  • may control germline stem cell self-renewal in the ovary
  • involved in multiple nuclear functions, including transcriptional regulation, replication, and chromatin assembly
  • mediate nucleosome assembly and spacing during replication
  • possesses nucleosome-dependent ATPase activity, whereas RSF1 (HBXAP) functions as a histone chaperone
  • both the full-length RSF1 and SMARCA5 were required to form a functional RSF complex responsible for the growth suppression effects
  • BAZ1A and SMARCA5, accumulate rapidly at DNA double-strand breaks and are required for DSB repair
  • evolutionarily conserved nucleosome remodelling factor that regulates gene expression and chromosome organization genome-wide
  • controls chromatin organization and histone H1 dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation
  • SMARCA1, SMARCA5 are ATP-dependent chromatin remodelling proteins that assemble, reposition and space nucleosomes, and are robustly expressed in the brain
  • SMARCA5 targeting to DNA damage-stalled transcription sites is controlled by an ATP-hydrolysis-dependent scanning and proofreading mechanism, highlighting how SWI2/SNF2 chromatin remodelers identify and bind nucleosomes containing damaged DNA
  • SMARCA5 contributes to breast cancer cell proliferation and invasion
  • SMARCA5 and SMARCA1 position nucleosomes adjacent to CTCF and other transcription factors
  • SMARCA4 and SMARCA5 are catalytic subunits of distinct ATP-dependent chromatin remodeling complexes implicated in transcriptional regulation
  • is essential for the establishment of lens vesicle polarity, partitioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear degradation
  • is one of the most conserved chromatin remodeling factors
  • SMARCA5 plays indispensable roles during early hematopoiesis and erythropoiesis
  • ISWI proteins SMARCA1, SMARCA5 interact with BAZ (bromodomain adjacent to PHD zinc finger) domain containing proteins to generate eight distinct remodeling complexes (
  • RSF1 is recruited at double strand break (DSB) sites and regulates ataxia telangiectasia mutated (ATM) -dependent checkpoint pathway upon DNA damage for the efficient repair
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the nucleolar chromatin remodeling complexes and of the chromatin remodeling and spacing factor RSF
  • complexing with BAZ1B (BAZ1B/SMARCA5 complex has a role in the maintenance of chromatin structures during DNA replication)
  • part of a multiprotein complex that contains WICH, a chromatin remodelling complex containing BAZ1B (Williams syndrome transcription factor), SMARCA5, MYO1C
  • principal determinant of rDNA silencing is the nucleolar remodelling complex, NoRC, that consists of BAZ2A and the ATPase SMARCA5
  • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • RAD21 for chromatin remodeling
  • binds to unacetylated histone H4 tails, suggesting that deacetylase activity of the corepressor complex is critical to its function
  • interacting with HDAC3 (HDAC3 as well as SMARCA5 are required for nucleosomal organization on the thyroid hormone receptor target gene)
  • RSF1 interacts with sucrose nonfermenting protein 2 homologue (SNF2H) to form a chromatin remodeling complex that participates in several biological processes
  • CECR2 contributes to spermatogenesis and forms a complex that includes the other ISWI ATPase SMARCA5 in the testis
  • functional interaction between CEBPB and SMARCA5/BAZ1A, characterized mainly by suppression of CEBPB transactivation activity in the presence of SMARCA5 and BAZ1A
  • CNBP up-regulates TBX2 and SMARCA5, and down-regulates WNT5B gene expression
  • RSF1 facilitates the assembly of centromere proteins CENPS and STRA13 at sites of DNA damage, while SMARCA5 was not required for these events
  • SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding
  • chromatin remodeling factor SMARCA5 is a novel binding partner of XRCC1, with their interaction dependent on the casein kinase 2-mediated constitutive phosphorylation of XRCC1
  • interacts with different accessory proteins and represents a molecular motor for DNA replication, repair, and transcription
  • mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage
  • temporal regulation of RSF1 levels at its post-translational modification by SMARCA5 and ATM is essential for efficient DNA repair
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer and correlated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS