basic FUNCTION
| involved in ubiquitin-dependent protein catabolism |
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regulating SIAH2 ligase stability and activity via noncatalytic ubiquitin-binding domains |
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responsible for MITF deubiquitination, utilizing a short hairpin RNA library against known deubiquitinating enzymes |
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may function differently from USP5 in cellular deubiquitination processes |
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USP13 is a AMFR-associated DUB that eliminates ubiquitin conjugates from UBL4A to maintain the functionality of BAG6 |
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USP5 regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains while USP13 regulates stress granules through deubiquitylating protein-conjugated ubiquitin chains |