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FLASH GENE
Symbol TNFRSF10B contributors: mct - updated : 07-01-2011
HGNC name tumor necrosis factor receptor superfamily, member 10b
HGNC id 11905
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4154 - 440 - 2007 17273769
10 - 4067 - 411 - 2007 17273769
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveintestinelarge intestinecolon  
 liver    
Reproductivefemale systemovary  highly
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage highly in tumor cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text widely in fetal tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative signal peptide, with two extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail with an intracellular DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfrsf10b
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • inducing a caspase-dependent apoptotic pathway, FADD dependent
  • acting as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL-induced apoptosis in B-cell lymphoma
  • playing a role as a regulator of megakaryocytopoiesis
  • with TNFSF10 and TNFRSF10A, play an important role in inflammation
  • TNFRSF10B- death signaling contributes to palmitate-induced apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • its signaling promotes hepatocyte lipoapoptosis
  • a component
  • death signal mediated by TNF-related apoptosis-inducing ligand (TNFSF10) receptor 2/death receptor 5 (DR5) may be a key regulator of cholestatic liver injury
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • FADD
  • protein
  • binding APO2L
  • receptor of TNFSF10
  • TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B (PMId: 24085293)
  • cell & other
    REGULATION
    induced by TP53,inducible
    by luteolin (plays a role in luteolin-induced apoptosis)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary glioblastoma multiforme
    tumoral     --low  
    in B-cell non-Hodgkin lymphoma (B-NHL)
    tumoral somatic mutation      
    in head and neck cancer,with a mutation also present in the germ line of an affected patient
    tumoral       gain of function
    in colon cancer
    constitutional     --over  
    in patients with nonalcoholic steatohepatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliversteatosis
    caspase inhibitors in steatohepatitis or other approaches to reduce TNFRSF10B activation hold promise to ameliorate hepatocyte lipoapoptosis in fatty liver disease
    cancerbrainglioma/neuroblstoma
    target for future TNFSF10 therapy of glioblastoma
    cancer  
    application of TNFSF10 or anti-TNFSFR10B mAb therapies to cancer patients
    cancer  
    TNFRSF10B-stimulated JNK activation and its consequent fluxes into the pro-autophagic signaling pathways contribute to the autophagic cell death in cancer cells
    cancer  
    cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis
    ANIMAL & CELL MODELS