basic FUNCTION
| potential transcriptional regulator |
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core active zone protein not essential for synapse formation but playing an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses |
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scaffolding protein involved in organizing the presynaptic cytoskeleton |
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thought to participate in the organization of the cytomatrix at the site of neurotransmitter release |
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is important for organizing the presynaptic active zone during the postnatal maturation of glutamatergic synapses |
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with PCLO play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release (Mukherjee 2010) |
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function as tethering proteins that mediate efficient synaptic vesicle clustering, but that neither piccolo nor bassoon has a direct role in either synapse formation or neurotransmitter release (Mukherjee 2010) |
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is a cytosolic scaffolding protein essential for the active zone assembly in ribbon synapses and some brain synapses |
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CACNA1A, CACNA1B, preferentially accumulate at neuromuscular junctions (NMJs) active zones and play essential role in synaptic transmission in conjunction with the active zone protein BSN |
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BSN and environmental illumination synergistically and complementarily act as organizers of the ribbon synapse |
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promotes vesicular replenishment and, consequently, a large standing pool of readily releasable synaptic vesicles at the endbulb synapse |
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is a major regulator of the molecular composition of the presynaptic neurotransmitter release sites |
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controls presynaptic autophagy through ATG5 |