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FLASH GENE
Symbol VNN1 contributors: - updated : 05-05-2006
HGNC name vanin 1
HGNC id 12705
RNA
TRANSCRIPTS type messenger
text minor transcripts were also detected (Galland)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveintestinesmall intestine   
 liver    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
putative GPI anchored cell surface molecule,containing a leader peptide and a putative GPI-cleavage motif
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Vnn1
ortholog to Drosophila Vanin-like
intraspecies homolog to biotinidase
Homologene
FAMILY
  • carbon-nitrogen hydrolase family
  • vanin subfamily
  • CATEGORY adhesion , enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • secreted
  • membrane-associated protein by a GPI-anchor
  • basic FUNCTION
  • involved in lymphocyte migration in cell adhesion and in the colonization of the thymus by hematopoietic precursor cells
  • regulation of Sertoli cells
  • pantetheinase activity playing a role in oxidative-stress response
  • hydrolyzing specifically one of carboamide linkages in D-pantetheinase thus recycling pantothenic acid
  • ectoenzyme
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS