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FLASH GENE
Symbol RAD1 contributors: mlc/pgu - updated : 15-12-2007
HGNC name RAD1 homolog (S. pombe)
HGNC id 9806
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - - - - 1998 9660799
- splicing - - - - 1998 9660799
- - 4683 - 282 - 2007 17583730
- - 4765 - 282 - 2007 17583730
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • two regions containing potential leucine zipper motifs, functioning as a 3'-5' endonuclease
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD17
    homolog to yeast S.pombe Rad
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cell cycle G2 checkpoint control gene
  • also involved in DNA repair
  • play a role in DNA repair and cell cycle regulation
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with RAD9 and HUS1 for response to radiation exposure or incomplete DNA replication (RAD9-RAD1-HUS1 checkpoint complex stimulates flap endonuclease 1)
  • RAD17/ATR/RAD1, is the 9-1-1 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by its N terminus with HUS1
  • by its C terminus with the C terminus of RAD9
  • DNA2 shows partial redundancy for the replication checkpoint with checkpoint initiators RAD9-RAD1-HUS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS