basic FUNCTION
| putative regulator of the kinetic neural development |
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transcriptional activator that plays a crucial role in forebrain development |
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plays two distinct roles in forebrain development: at mid-gastrulation functions to maintain the organizer region, and other function occurs in the dorsal neurectoderm of the developing brain where it acts to promote formation of the dorsal signaling centre responsible for roof-plate and choroid plexus development |
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upregulates EPHB1 expression and define a link between a transcription factor and expression of a guidance receptor protein essential for axon guidance at the vertebrate midline |
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potential existence of an additional EPHB1-independent pathway controlled by ZIC2 that contributes to retinal axon divergence at the midline |
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necessary and sufficient for the specification of retinal ganglion cells (RGCs) that project ipsilaterally at the optic chiasm midline |
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controls the refinement of eye-specific inputs in the visual targets by regulating directly the expression of SLC6A4, which is involved in the modulation of activity-dependent mechanisms during the wiring of sensory circuits |
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necessary and sufficient for the expression of SLC6A4 in the retina |
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controls specifically the refinement of ipsilateral but not contralateral axons in the primary visual targets by controlling directly the expression of SLC6A4 |
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ZIC1, ZIC2, ZIC3, are strongly expressed in immature retinal progenitor cells, and their roles in retinal differentiation and proliferation are suggested by gain-of-function analysis |
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ZIC1, and ZIC2 function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling |
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ZIC1 and ZIC2 are required for coordinating mature neuronal gene expression patterns |
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similar activities of ZIC1, ZIC2, and ZIC3, suggesting that Zics are redundant in terms of retinal cell differentiation |