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FLASH GENE
Symbol PAPSS2 contributors: npt/mct - updated : 10-10-2016
HGNC name 3'-phosphoadenosine 5'-phosphosulfate synthase 2
HGNC id 8604
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3874 - 619 - 2002 11931637
also called PAPS synthase 2a or variant 2
12 - 3874 - 614 - 2002 11931637
  • also called PAPS synthase 2b or variant 2
  • contains notably an extra five amino acid sequence GMALP
  • EXPRESSION
    Rna function the most significant levels of mRNA were found in condensing and proliferating chondrocytes
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestivemouthtongue    Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly Homo sapiens
    Connectivecartilage  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, major variant in growth plate cartilage
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PAPSS1 (77 p100)
    Homologene
    FAMILY
  • sulfate adenyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • PAPSS1 was predominantly nuclear, whereas PAPSS2 localised mainly within the cytoplasm
  • basic FUNCTION
  • catalyzing the activation of sulfate in two steps, synthesis of adenosine 5'-phosphosulfate and phosphorylation of APS to generate 3'-phospho-adenosine 5'-phosphosulfate (PAPS)
  • may have a important role in skeletogenesis during postnatal growth
  • may be having a important role of the gene product for cartilage growth and development
  • might regulate osteoblast alkaline phosphates activity and cell mineralization, probably through Smads signal pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with PAPSS1
  • enhanced PAPSS2/VCAN sulfation axis is essential for SNAI1-mediated breast cancer cell migration and metastasis
  • cell & other
    REGULATION
    induced by during chondrogenesis
    Other regulated by extracellular signal-regulated protein kinase, protein kinase C, and p38 kinase, signaling molecules known to regulate chondrogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) SEMD4 , BCYM4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess
    constitutional       loss of function
    causes androgen excess via impaired DHEA sulfation, and is associated with a phenotype resembling polycystic ovary syndrome
    Susceptibility to osteoarthritis(minor role in japanese)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS