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FLASH GENE
Symbol PPIB contributors: mct/npt/pgu - updated : 23-10-2015
HGNC name peptidylprolyl isomerase B (cyclophilin B)
HGNC id 9255
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1045 - 216 - 2009 19503092
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic signal sequence
  • a central PPI and CSA binging domains
  • a C terminal variable region
  • conjugated HemoP
    mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class M family
  • cyclophilin-type PPIase family
  • PPIase B subfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    text
  • secreted
  • was dispersed throughout the cytoplasm
  • basic FUNCTION
  • may be regulating cyclosporine A-mediated immunosuppression
  • plays a critical role in IRF3 activation
  • having a peptidyl-prolyl cis-trans isomerase activity that functions as a transcriptional inducer for STAT5 and as a ligand for CD147
  • play pivotal roles, yet at different signaling levels, for STAT3 activation and function
  • responsible for posttranslational modifications of type I collagen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    Ca2+ signal transduction pathway
    a component
  • P3H1 forms a hetero-trimeric complex with CRTAP and cyclophilin B (PPIB)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • binding glycosaminoglycans requirred for cyclophilin to trigger T cell adhesion to extracellular matrix
  • bound by calcium modulating cyclophilin ligand CAMLG
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with FHOD1
  • specifically interacts with STAT3
  • TRPV6 accessory protein with potential involvement in TRPV6 channel activation through its peptidyl-prolyl cis/trans isomerase activity
  • GOLM1 and PPIB are interacting partner (role of Dymeclin in secretory pathways essential to endochondral bone formation during early development)
  • is an important factor in the proper maturation and secretion of ADAMTS13
  • IER3IP1, PPIB, EMC7, SPINT2, C14orf1/PEBP28, TMEM147, YIPF6, and KRTCAP2 interacting with SLC41A1
  • cell & other
  • binding CD147 (basigin BSG) serving as receptor for extracellular matrix
  • REGULATION
    inhibited by cyclosporin A
    ASSOCIATED DISORDERS
    corresponding disease(s) OIIX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    in malignant breast epithelium may contribute to the pathogenesis of this disease through its regulation of the expression of hormone receptors and gene products that are involved in cell proliferation and motility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Adamts13 levels are significantly reduced in the plasma of CypB-deficient mice