protein
| interacting with CRM1, leading to the translocation of CDC7 from nucleus to cytoplasm |
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interacts with and phosphorylates Claspin (CLSPN) (CDC7 is potentially required for activation of the ATR-CHEK1 checkpoint pathway through regulation of Claspin) |
|
RAD18 is a substrate of the essential protein kinase CDC7 |
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CDC7-DBF4 interaction with CDC5 |
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bipartite interaction between CDC7 and DBF4 subunits facilitates ATP binding and substrate recognition by the CDC7 kinase |
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SMAD3 is required for CDC7 function in inducing SMC promoter activities and marker gene expression |
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role for CDC7 -mediated phosphorylation of MCM2 in the response to replicative stress, including some forms of DNA damage |
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CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis |