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FLASH GENE
Symbol EIF6 contributors: mct - updated : 01-02-2015
HGNC name eukaryotic translation initiation factor 6
HGNC id 6159
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 1114 26 245 - 2011 21536732
  • 7 exons
  • encoding the same isoform than variant 2 encode
  • 6 splicing 1259 26 245 - 2011 21536732
  • 6 exons
  • differing in the 5' UTR compared to variant 1
  • encoding the same isoform than variant 1
  • - splicing 1083 11 108 - 2011 21536732
  • 5 exons
  • differing in the 5' UTR and lacking an alternate exon compared to variant 1 which causes a frameshift
  • encoding the same isoform than the variant 5
  • 5 splicing 1057 2 226 - 2011 21536732
  • 5 exons
  • containing an alternate segment compared to variant 1 which causes a frameshift
  • lacking an alternate exon which corrects the frameshift compared to variant 1
  • - splicing 938 11 108 - 2011 21536732
  • 6 exons
  • lacking an alternate exon compared to variant 1 which causes a frameshift
  • encoding the same isoform than variant 3
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     liver   moderately
     pancreas exocrine   moderately
     pharynx   highly
     salivary gland   highly
     stomach   moderately
    Endocrineparathyroid   highly
    Lymphoid/Immunetonsils   moderately
    Nervousnervecranial nerve  moderately
    Reproductivefemale systemovary  moderately
     female systemuteruscervix moderately
     male systemprostate  highly
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion highly in blood, predominantly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES fibrous
    STRUCTURE
    motifs/domains
  • prokaryotic membrane lipoprotein lipid attachment site
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Itgb4bp (98.8 pc)
    homolog to murine Itgb4bd (98 pc)
    Homologene
    FAMILY
  • eIF-6 family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus,nucleolus
    text
  • associated with the intermediate filament cytoskeleton
  • in the nucleolus, EIF6 is a component of the pre-ribosomal particles and is required for the biogenesis of 60S subunits, whereas in the cytoplasm it mediates translation downstream from growth factors
  • basic FUNCTION
  • acting as a translation initiation factor
  • linking ITGB4 to intermediate filament cytoskeleton
  • preventing association of the 60S ribosomal subunit with the 40S ribosomal subunit to form the 80S initiation complex
  • is the first EIF associated with the large 60S subunit that regulates translation in response to extracellular signals
  • necessary protein with a unique anti-association activity, which prevents the interaction of 40S ribosomal subunits with 60S subunits through its binding to 60S ribosomes
  • necessary for tissue-specific growth and oncogene-driven transformation, and could be a new rate-limiting step for the initiation of translation
  • removal of the assembly factor eukaryotic initiation factor 6 (EIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits
  • controls translation by regulating 80S subunit formation
  • rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth
  • is a ribosome anti-association factor that has been implicated in translational initiation and in ribosome synthesis
  • CELLULAR PROCESS protein, translation regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bindign to the fibronectin type III domains of ITGB4
  • SBDS and the GTPase elongation factor-like 1 (EFL1) directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFL1 but not phosphorylation of EIF6 Ser 235
  • is one of the downstream effectors of NOTCH1 in the pathway that controls cell motility and invasiveness
  • cell & other
  • binding to the 60S ribosomal subunit
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal tumor (transition from benign to malignant tumor)
    tumoral     --over  
    in head and neck carcinomas and their lymph node metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    Modulation of eIF6 activity, independent from EIF4F complex, may lead to a therapeutical avenue in tumor therapy
    ANIMAL & CELL MODELS
  • eIF6(+/-) mice resist to Myc-induced lymphomagenesis and have prolonged tumor-free survival and reduced tumor growth, and are also protected by Tp53 loss