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FLASH GENE

Symbol

ANKRD17

contributors: mct/npt - updated : 22-06-2009

HGNC name	ankyrin repeat domain 17
HGNC id	23575

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 34 - 9390 isoform 1 274 2603 - Jones, Deng (2009) variant 2 33 - 8637 isoform 2 260 2352 ubiquitous Jones, Deng (2009)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system uterus       Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two clusters of a total 25 ankyrin repeats at its N terminus
	one NES (nuclear exporting signal)
	one NLS (nuclear localization signal) in the middle
	one RXL motif at its C terminus

HOMOLOGY

interspecies

ortholog to murine Gtar

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome
text	localized to the nucleus (Deng 2009)

basic FUNCTION	may be directly involved in the DNA replication process
	is an important downstream effector of cyclin E/CDK2 and positively regulates G1/S transition (Deng 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with DNA replication factors including MCM family members, CDC6 and PCNA (Deng 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS