Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LMNB2 contributors: mct/npt - updated : 04-05-2017
HGNC name lamin B2
HGNC id 6638
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4653 67.7 600 - Abdurashidova (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 salivary gland   highly
Endocrinepancreas   lowly
 thyroid   moderately
Lymphoid/Immunelymph node   highly
Nervousbrain   lowly
Reproductivemale systemprostate  moderately
Respiratorylung   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text eye, embryonic tissue, umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal head domain
  • a central rod domain
  • a nuclear localization signal (NLS)
  • a C terminal tail with a CAAX doamin (a farnesyl group is attached to the cystein residue of the &
  • 8722;CAAX box by a farnesyltransferase)Dechat 2008)
    mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Lmnb2 (84.58 pc)
    homolog to murine Lmnb2 (83.53 pc)
    Homologene
    FAMILY
  • intermediate filament family, type V
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nuclear envelope,int
    intracellular,nuclear envelope,lamina
    basic FUNCTION
  • involved in nuclear stability, chromatin structure and gene expression
  • responsible of DNA replication origin
  • LMNA, LMNB1, LMNB2 not only constitute a scaffold for nuclear shape, rigidity and resistance to stress but also contribute to the organization of chromatin and chromosomal domains
  • LMNB2 interaction with MCM7 promotes non-small cell lung cancer (NSCLC) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • coiled coil dimers associated to form a tetrameric subunit from which IFs assemble
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TOP1, TOP2A in a cell cycle-modulated manner
  • lamin B2 binds to the C-terminus of MCM7, and competes with the binding of the tumor suppressor retinoblastoma (RB1) protein
  • cell & other
    REGULATION
    Other diassembly at the start and reassembly at the end of mitosis mediated by phosphorylation,dephosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s) LPPA , EPM9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in acquired partial lipodystrophy (Barraquer-Simons syndrome)
    constitutional germinal mutation      
    mutations will be identified in children with severe developmental brain disorders (Coffinier 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Lmnb2&
    8722;/&
    8722; mice had a smaller cerebellum with a complete absence of foliation, and the hippocampus was also abnormal (Coffinier 2010)