Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ADAMTS4 | contributors: mct - updated : 18-09-2015 |
HGNC name | ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
HGNC id | 220 |
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RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
tissue |
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cells |
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cell lineage
cell lines
| osteoarthritic cartilage | fluid/secretion
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at STAGE |
physiological period | pregnancy |
Text | placenta |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | MetalloP |
isoforms | Precursor | pro-form of ADAMTS-4 is not catalytically active and only a limited number of mechanisms mediate its N-terminal activation |
HOMOLOGY |
interspecies | homolog to murine secretory protein |
Homologene |
FAMILY |
CATEGORY | adhesion , enzyme |
SUBCELLULAR LOCALIZATION | extracellular |
basic FUNCTION | |
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CELLULAR PROCESS | protein, degradation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, cofactor, |
protein | |
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cell & other |
REGULATION |
induced by | interleukin 1 |
inhibited by | TIMP3 |
alpha(2)-macroglobulin in a concentration-dependent manner, |
Other | its expression was found to be regulated by EWS-FLI1 fusion gene-dependent manner ![]() |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
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| Therapy target
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ANIMAL & CELL MODELS |