basic FUNCTION
| MAP kinase kinase kinase kinase 4, specifically activating the JNK signaling through the pathway TAK1 |
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plays a crucial role in osteopontin (OPN)-induced mitogen-activated protein kinase/I kappa B alpha kinase-dependent nuclear factor kappa B (NF kappa B)-mediated promatrix metalloproteinase-9 activation |
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is a key upstream mediator of TNF action on the beta cell, making it a potential therapeutic target for preservation of beta cell function in type 2 diabetes |
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is a negative regulator of myogenic differentiation and hypertrophy |
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suppressor of skeletal muscle differentiation, acting through a MYF5-dependent mechanism |
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inhibits adipose lipogenesis by suppression of SREBF1 in an AMPK- and MTOR-dependent but JNK-independent mechanism |
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unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase |
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pathways, in regulating tumor cell survival |
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required for the activation of CD4(+) T cells |
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is essential for CD4(+) T cell proliferation, activation and cytokine production |
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directly phosphorylates TRAF2, leading to its lysosomal degradation and subsequent inhibition of IL6 production |