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FLASH GENE
Symbol G3BP2 contributors: mct - updated : 11-12-2012
HGNC name GTPase activating protein (SH3 domain) binding protein 2
HGNC id 30291
RNA
TRANSCRIPTS type messenger
text Variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4410 54 482 - 1996 9575347
12 - 4275 54 482 - 1996 9575347
11 - 4311 51 449 - 1996 9575347
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Ras-GTPase-activating SH3 domain binding protein G3BP
Homologene
FAMILY
CATEGORY enzyme , signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,granule
text G3BP2 and PRKCA, relocate to and co-localize in stress granules, but not to P-bodies, when cells are subjected to stress
basic FUNCTION
  • putative DNA and RNA helicase
  • its arginine methylation appears to be a WNT3A-sensitive 'switch' regulating LRP6 phosphorylation and canonical WNT-CTNNB signaling
  • G3BP1 and G3BP2 play a role in the formation of SGs (stress granules) in various cells and thereby recovery from these cellular stresses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ras-GTPase-activating protein
  • its expression resulted in significant in significant reduction in MDM2-mediated TP53 ubiquitylation and degradation
  • PRKCA binds G3BP2 and regulates stress granule formation following cellular stress
  • cell & other
    REGULATION
    Other methylated in response to WNT3A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS