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FLASH GENE

Symbol

G3BP2

contributors: mct - updated : 11-12-2012

HGNC name	GTPase activating protein (SH3 domain) binding protein 2
HGNC id	30291

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	Variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_203505 12 - 4410 NP_987101 54 482 - 1996 9575347 NM_012297 12 - 4275 NP_036429 54 482 - 1996 9575347 NM_203504 11 - 4311 NP_987100 51 449 - 1996 9575347

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Ras-GTPase-activating SH3 domain binding protein G3BP

Homologene

FAMILY

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	G3BP2 and PRKCA, relocate to and co-localize in stress granules, but not to P-bodies, when cells are subjected to stress

basic FUNCTION	putative DNA and RNA helicase
	its arginine methylation appears to be a WNT3A-sensitive 'switch' regulating LRP6 phosphorylation and canonical WNT-CTNNB signaling
	G3BP1 and G3BP2 play a role in the formation of SGs (stress granules) in various cells and thereby recovery from these cellular stresses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	Ras-GTPase-activating protein
	its expression resulted in significant in significant reduction in MDM2-mediated TP53 ubiquitylation and degradation
	PRKCA binds G3BP2 and regulates stress granule formation following cellular stress

cell & other

REGULATION

Other

methylated in response to WNT3A

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in human breast cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS