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FLASH GENE
Symbol DAGLA contributors: mct/shn - updated : 29-09-2012
HGNC name diacylglycerol lipase, alpha
HGNC id 1165
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 5761 115 1042 - - 14610053
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly Homo sapiens
Digestiveintestine   lowly Homo sapiens
 stomach   lowly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunespleen   lowly Homo sapiens
Nervousbrain   moderately Homo sapiens
Reproductivefemale systemplacenta  lowly Homo sapiens
 male systemprostate  lowly Homo sapiens
Respiratorylung   lowly Homo sapiens
Urinarykidney   lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage Homo sapiens
NervousPurkinje cell Homo sapiens
not specificadipocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Dagla, Mus musculus
ortholog to Dagla, Rattus norvegicus
ortholog to DAGLA, Pan troglodytes
Homologene
FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • catalyzing the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), an endocannabinoid with an important role in retrograde trans-synaptic suppression of synaptic transmitter release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text formation of the most prevalent endocannabinoid, 2-arachidonoylglycerol in the brain
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • fluorogenic and chromogenic substrates
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for SCA20
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • endocannabinoid-mediated retrograde synaptic suppression was totally absent in the cerebellum, hippocampus, and striatum of DGLalpha knockout mice