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FLASH GENE
Symbol PRORP contributors: mct - updated : 24-11-2021
HGNC name protein only RNase P catalytic subunit
HGNC id 19958
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2825 - 567 - 2006 17114934
8 - 2873 - 583 - 2006 17114934
8 - 2320 - 488 - 2006 17114934
7 - 1637 - 211 - 2006 17114934
6 - 1589 - 211 - 2006 17114934
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
Nervousbrain    
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumhair cell receptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a metallonuclease domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transfer RNA recognition by PRORP proteins is similar to that by ribonucleoprotein RNase P
  • TRMT10C along with HSD17B10 and KIAA0391, form the mitochondrial ribonuclease P (mt-RNase P) complex that cleaves the 5prime ends of mt-tRNAs from polycistronic precursor transcripts
  • is the nuclease component of the mtRNase P complex and requires a two-protein S-adenosyl-methionine (SAM)-dependent methyltransferase MRPP1/2 subcomplex to function
  • endonuclease PRORP is recruited and activated through interactions with its PPR and nuclease domains to ensure precise pre-tRNA cleavage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RNase P consists of three different proteins TRMT10C, MRPP2 (HSD17B10) and MRPP3 (KIAA0391), each of which is essential for RNase P function
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRMT10C and HSD17B10 both deliver the pre-tRNA substrate and activate KIAA0391 through an induced-fit process
  • presence of PRORP can enhance the methylation activity of TRMT10C/HSD17B10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to myocardial infarction and coronary artery disease
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS