basic FUNCTION
| positive and negative regulation of transcription |
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may contribute to important and specific acetylation events occurring during gametes and embryo development |
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MOZ-TIF2 acts as a dominant inhibitor of the transcriptional activities of CBP-dependent activators such as nuclear receptors and p53 |
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may play an essential role for normal adult neurogenesis |
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KAT6A/KAT6B are histone acetyltransferase (HATs) important for different developmental programs and have been implicated in leukemogenic and other tumorigenic processess |
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tandem PHD fingers of KAT6A/KAT6B acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin |
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MED12 and KAT6B are chromatin-modifying enzymes implicated in Ohdo syndrome and the development of uterine leiomyomata and other tumors strongly suggests that both genes are functionally related |