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FLASH GENE
Symbol XPO6 contributors: mct - updated : 19-11-2011
HGNC name exportin 6
HGNC id 19733
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 4422 - 1125 - 2003 14592989
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrain    
 nerve   highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion lymph, blood
at STAGE
physiological period fetal
Text umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an importin N-terminal domain
HOMOLOGY
Homologene
FAMILY exportin family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleolus
intracellular,nuclear envelope,pore
basic FUNCTION
  • recruit cargo in the nucleoplasm in the presence of RAN-GTP and form ternary export complexes
  • mediates nuclear export of profilin-actin complexes
  • first example of a strictly developmentally regulated nuclear transport pathway
  • reduction of its activity leads to actin accumulation via failure of RANGTP restoration and NUTF2 sequestration in the nuclei of senescent cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other reduction of exportin 6 activity leads to actin accumulation, in nuclei that is a universal phenomenon of cellular senescence
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly reduced in the replicative senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS