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FLASH GENE
Symbol ZFYVE26 contributors: shn - updated : 03-01-2014
HGNC name zinc finger, FYVE domain containing 26
HGNC id 20761
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
42 - 9688 284.6 2539 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly Homo sapiens
 placenta   highly Homo sapiens
Lymphoid/Immunethymus   highly Homo sapiens
Nervousbrain   predominantly Homo sapiens
 spinal cord   moderately Homo sapiens
Reproductivemale systemtestis  highly Homo sapiens
Respiratorylung   highly Homo sapiens
Visualeyeretina  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FYVE-type zinc finger domain
  • a putative zinc finger C2H2 and leucine zipper domains
  • predicted to have secondary structures containing alpha-solenoids
  • HOMOLOGY
    interspecies ortholog to Zfyve26, Mus musculus
    ortholog to Zfyve26, Rattus norvegicus
    ortholog to ZFYVE26, Pan troglodytes
    ortholog to zfyve26, Danio rerio
    Homologene
    FAMILY
  • FYVE-finger family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • localizes to the endosomal membrane traffic compartment, suggesting that the long axons of the corticospinal tract may be especially vulnerable to endosomal dysfunction
  • localizes on a late endosomal/lysosomal compartments
  • broadly expressed in neurons, associates with intracellular vesicles immunopositive for the early endosomal marker EEA1, and co-fractionates with a component of the AP5 complex
  • basic FUNCTION
  • may be playing a role in intracellular trafficking
  • involved in the abscission step during cytokinesis
  • important for proper development of the axons of spinal motor neurons
  • role in autophagy and required for autophagosome maturation
  • involved in the endolysosomal system
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • microtubule motor KIF13A and tetratricopeptide repeat domain 19, TTC19
  • KIAA0415
  • AP-5 subunits
  • Beclin 1, Vps34, Rubicon and UVRAG
  • cell & other phosphatidylinositol-3-phosphate (PtdIns(3)P)
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG15
    Susceptibility
  • atypical juvenile parkinsonism
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SPG15 knock-down in zebrafish by morpholino antisense oligonucleotides lead to locomotor impairment and abnormal branching of spinal cord motor neurons at the neuromuscular junction
  • SPG15 knockdown causes the cation-independent mannose 6-phosphate receptor to become trapped in clusters of early endosomes as well as the tubulation of EEA1-positive endosomesof HeLa cellof HeLa cells
  • autophagy defects with autophagosome accumulation is observed also in neuronal cells upon spastizin silencing
  • Zfyve26 knockout mice develop late-onset spastic paraplegia with cerebellar ataxia, display axon degeneration and progressive loss of both cortical motoneurons and Purkinje cells in the cerebellum
  • an increase of Lamp1-positive membrane compartments with higher densities in Zfyve26 knockout mice