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FLASH GENE

Symbol

ZFYVE26

contributors: shn - updated : 06-09-2012

HGNC name	zinc finger, FYVE domain containing 26
HGNC id	20761

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015346.3 42 - 9688 NP_056161 284.6 2539 - -

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Homo sapiens   placenta       highly Homo sapiens Lymphoid/Immune thymus       highly Homo sapiens Nervous brain       predominantly Homo sapiens   spinal cord       moderately Homo sapiens Reproductive male system testis     highly Homo sapiens Respiratory lung       highly Homo sapiens Visual eye retina     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one FYVE-type zinc finger domain
	a putative zinc finger C2H2 and leucine zipper domains

HOMOLOGY

interspecies	ortholog to Zfyve26, Mus musculus
	ortholog to Zfyve26, Rattus norvegicus
	ortholog to ZFYVE26, Pan troglodytes
	ortholog to zfyve26, Danio rerio

Homologene

FAMILY

FYVE-finger family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,endosome
text	localize to the endosomal membrane traffic compartment, suggesting that the long axons of the corticospinal tract may be especially vulnerable to endosomal dysfunction

basic FUNCTION	may be playing a role in intracellular trafficking
	involved in the abscission step during cytokinesis
	important for proper development of the axons of spinal motor neurons

CELLULAR PROCESS	cell cycle, division, mitosis

PHYSIOLOGICAL PROCESS

nervous system , cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	microtubule motor KIF13A and tetratricopeptide repeat domain 19, TTC19
	KIAA0415

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG15

Susceptibility

atypical juvenile parkinsonism

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

SPG15 knock-down in zebrafish by morpholino antisense oligonucleotides lead to locomotor impairment and abnormal branching of spinal cord motor neurons at the neuromuscular junction