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FLASH GENE
Symbol WWP2 contributors: mct - updated : 22-08-2013
HGNC name WW domain containing E3 ubiquitin protein ligase 2
HGNC id 16804
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 splicing 4527 99 870 - 2011 21750408
14 splicing 3690 - 431 - 2011 21750408
10 splicing 2659 - 335 - 2011 21750408
24 - 4555 - 870 - 2011 21750408
9 - 2682 - 870 - 2011 21750408
21 - 4245 - 754 - 2011 21750408
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage  highly Homo sapiens
Muscularstriatumcardiac  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C2 domain
  • four WW (phosphoserine- or phosphothreonine binding) domains
  • a C terminal HECT domains (conserved cysteine characteristic of E3 ubiquitin ligase)
  • HOMOLOGY
    Homologene
    FAMILY NEDD4-like protein family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • ubiquitin-protein ligase activity
  • important regulator of the POU5F1 protein level in human embryonic stem cells
  • crucial role in controlling endogenous POU5F1 protein levels during differentiation processes of embryonal carcinoma cells
  • involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes
  • functional E3 ubiquitin ligase for PTEN that plays a vital role in tumour-cell survival
  • developmental role for WWP2 in chondrogenesis via mechanisms involving cartilage-specific transcription factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • atrophin 1 binding
  • ZCCHC14
  • influences craniofacial patterning through its interactions with Goosecoid (GSC), a paired-like homeobox transcription factor that has an important role in craniofacial development
  • interacts exclusively with SMAD2, SMAD3 and SMAD7 in the TGFB pathway
  • direct target of SOX9 (interacts physically with SOX9 and is associated with SOX9 transcriptional activity via its nuclear translocation)
  • regulatory interaction between SOX9, WWP2 and MED25 defines the SOX9 transcriptional mechanisms of chondrogenesis in the forming palate
  • physically interacts with PTEN and mediates its degradation through a ubiquitylation-dependent pathway
  • plays a negative role by binding to ADARB1 and catalysing its ubiquitination and subsequent degradation
  • WWP2 mediated K48-linked ubiquitination and degradation of TICAM1 upon TLR3 activation
  • WWP2, an E3 ligase, is a novel TP73-associated protein that ubiquitinates and degrades TP73
  • phosphatase PPM1G is a functional switch that controls the balance between monomeric WWP2 and a WWP2/WWP1 heterodimeric state in the cell
  • WWP2, a homolog of the HECT-type ubiquitin ligase WWP1, interacts with and targets PAIP1 for ubiquitination and proteasomal degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice deficient in Wwp2 develop malformations of the craniofacial region