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FLASH GENE
Symbol ZNF217 contributors: mct - updated : 20-06-2017
HGNC name zinc finger protein 217
HGNC id 13009
RNA
TRANSCRIPTS type messenger
text alternative splicing of exon 4
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5632 115.3 1108 - 2005 16203743
8 C2H2 zinc fingers and proline-rich domain
- splicing - 110.5 1062 ? testis 2005 16203743
  • skipping exon 4
  • 8 C2H2 zinc fingers and proline-rich domain
  • 8 - 5653 115.3 1048 - 2007 17130829
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger motif, C2H2 type, Krueppel-like,
  • with eight zinc finger DNA binding motifs
  • a proline-rich activation domain
  • a typical Pro-X-Asp-Leu-Ser (PXDLS) motif that binds in CTBP1 PXDLS-binding cleft
  • a second motif, Arg-Arg-Thr (RRT), that binds a separate surface on CTBP1
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor protein that functions, at least in part, by associating with CTBP1
  • may play roles in both early- and late-stage breast cancer and can attenuate apoptotic signals resulting from telomere dysfunction as well as from doxorubicin-induced DNA damage
  • may promote neoplastic transformation by increasing cell survival during telomeric crisis and later stages of malignancy by increasing cell survival during chemotherapy
  • implicated with its associated proteins in a novel pathway that may have profound effects on cancer progression
  • transcriptional repressor protein, having, with its associated proteins in a novel pathway, profound effects on cancer progression
  • key factor in regulating ovarian cancer proliferation and progression
  • assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression
  • regulates expression of the ERBB3 receptor tyrosine kinase in breast cancer cells
  • implicated as an oncogene and in repressing the E-cadherin gene
  • disruption of active demethylation by the ZNF217 oncogene may be a paradigm for other oncogenic signals on DNA methylation dynamics
  • promoted epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and the TGFB1-activated Smad signaling pathway was identified as a major driver of ZNF217-induced EMT
  • alternatively spliced Kruppel-like transcription factor that has recently been implicated to play a role in carcinogenesis
  • may contribute to ovarian cancer invasion and metastasis, and is associated with worse clinical outcomes
  • orchestrates complex intracellular circuits as a new key regulator of tumorigenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ZNF217 and its associated proteins in a novel pathway that may have profound effects on cancer progression
    a component
  • ZNF217 complex consists of approximately six proteins and contains the transcriptional co-repressors RCOR1, AOS2, histone deacetylase (HDAC) 2 and C-terminal binding protein (CTBP1)
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • actiavating PI3K and AKT for its antiapoptotic activity
  • directly binds to and represses the E-cadherin gene (CDH1) promoter via a two-zinc finger domain that recognizes the consensus
  • is essential for recruitment of the CoREST Complex to the CDKN2B promoter
  • ZNF217/CoREST complex and specific DNMTs combine likely to generate a hypermethylated state resulting in repression of the CDKN2B gene
  • transcriptional repressor that inhibits SLC40A1 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in breast carcinoma with poor prognosis
    tumoral   amplification    
    in ovarian cancer
    tumoral        
    silencing of ZNF217 resulted in the effective inhibition of ovarian cancer cell growth and invasive ability
    tumoral     --over  
    in primary breast tumours had a higher risk of developing bone metastases
    tumoral     --over  
    promotes prostate cancer growth by restraining SLC40A1-conducted iron egress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a crucial mediator and indicator of bone metastasis
  • ZNF217 mRNA expression may represent a novel prognostic biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    future therapies targeting ZNF217 and/or the BMP signalling pathway may be beneficial by preventing the development of bone metastases
    ANIMAL & CELL MODELS