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FLASH GENE
Symbol CAT contributors: mct - updated : 19-10-2020
HGNC name catalase
HGNC id 1516
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2291 - 527 - 2019 30600457
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Cat
ortholog to dog cat
Homologene
FAMILY catalase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,interspace
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,peroxisome
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,lysosome
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in catabolic pathway of activated oxygen species and free radical detoxification
  • catalase overexpression has a protective role against UVB irradiation by preventing DNA damage mediated by the late ROS increase
  • catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species
  • heme enzymes, which catalyze decomposition of hydrogen peroxide to water and molecular oxygen
  • is an important antioxidant enzyme that dismutates hydrogen peroxide into water and molecular oxygen
  • catalase is a key enzyme in the metabolism of H2O2 and reactive nitrogen species, and its expression and localization is markedly altered in tumors
  • major peroxisome protein, plays a critical role in removing peroxisome-generated reactive oxygen species (ROS) produced by peroxisome enzymes
  • catalase plays an important role in pexophagy during nutrient deprivation
  • potential therapeutic effects in nonalcoholic fatty liver disease (NAFLD) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    heme group and NADP
    protein
  • transcription factors (PPARG,POU2F1), as well as genetic, epigenetic, and posttranscriptional processes, have emerged as crucial contributors to the regulation of catalase expression (PIMID: 26117330)
  • MARVELD1 interacting with CAT regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAT
    Susceptibility
  • to essential hypertension
  • to noise-induced hearing loss
  • Variant & Polymorphism
    Candidate gene
  • neurocognitive sequelae associated with radiation exposure can be reduced by overexpression of Mitochondrial CAT, operating through a mechanism involving the preservation of neuronal morphology
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice devoid of catalase develop an obese, pre-diabetic phenotype