basic FUNCTION
| functioning as GTPase-activating protein for G protein alpha i and q subunits |
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inhibiting signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form |
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implicated in a diverse set of cellular processes including centrosome and nuclear functions and stress-induced signaling pathways |
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microtubule-associated protein and a component of the mitotic spindle that may regulate microtubule polymerization and spindle organization |
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its activity towards G-protein alpha subunits is independent of its binding to RAP2A |
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facilitates the formation of a selective RAS.GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate HRAS-dependent neuritogenesis |
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integrator of G protein and MAPKinase signalling pathways |
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newly appreciated integrator of G protein and Ras/Raf signalling pathways |
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scaffolding protein that integrates G protein and HRAS/ERK/MAP kinase signaling pathways |
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key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory |
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brain scaffolding protein that integrates G protein and MAP kinase signaling pathways |
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with RIC8A are recruited from the cytosol to the plasma membrane in the presence of coexpressed GNAI1 in cells, suggesting formation of a functional protein complex with GNAI1 |