basic FUNCTION
| metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a by product |
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catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood (Schmiegelow 2009) |
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metabolizes thiopurine medications, including azathioprine and 6-mercaptopurine |
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is required for detoxification, through S-methylation, of 6-thioguanine nucleotides (TGNs), a byproduct of thiopurine metabolism |
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both TPMT and ABCC4 influence mercaptopurine disposition and toxicity |