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FLASH GENE
Symbol PTP4A1 contributors: shn/npt - updated : 28-12-2016
HGNC name protein tyrosine phosphatase type IVA, member 1
HGNC id 9634
RNA
TRANSCRIPTS type messenger
text contains 2 promoters : TATA box was identified in promoter P1 upstream of the non-coding first exon and a non-canonical internal promoter, P2, in the first intron that results in PRL-1 transcripts beginning 8 base pairs downstream of the 5'-end of exon 2 and causes no alteration in the encoded protein. An enhancer complex (PIEC), is localized to the first intron of the human PRL-1 gene (Peng et al, 1998)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 5099 21 173 in neurons and oligodendrocytes in the brain Diamond (1994); Takano (1996)
8 - 4918
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestine  moderately
 liver   lowly
 stomach   moderately
Endocrinepancreas   moderately
Gustatory (taste)tongue   moderately
Lymphoid/Immunespleen   lowly
 thymus   lowly
Nervousbrain   highly
Reproductivefemale systemoviduct  highly
 female systemuterus  highly
 female systemplacenta  moderately
 female systemuteruscervix highly
 female systembreast  moderately
 male systemprostate  moderately
 male systemtestis  highly
Respiratorylung   highly
Skin/Tegument    moderately
Urinarybladder   highly
 kidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly
cell lineage
cell lines HeLa, HepG2, Cvi, Burkitt lymphoma
fluid/secretion
at STAGE
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tyrosine-protein phosphatase domain
  • C-terminal polybasic region important for specific phosphoinositide recognition, with prenylation motif CAAX
  • mono polymer homomer , monomer
    HOMOLOGY
    interspecies ortholog to ptp4a1, Danio rerio
    ortholog to Ptp4a1, Rattus norvegicus
    ortholog to Ptp4a1, Mus musculus
    ortholog to PTP4A1, Pan troglodytes
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    basic FUNCTION
  • immediate early gene in regenerating liver, involved in cellular growth of the liver
  • may play a role in the development and maintenance of differentiating epithelial tissues
  • implicated in promoting cell growth, differentiation, and tumor invasion
  • enhancing cell proliferation, cell motility and invasive activity, and promotes cancer metastasis
  • may be a significant regulator in the development and metastasis of a variety of cancer types
  • may contribute to tumor development by the downregulation of p53 by a negative feedback mechanism
  • trimer formation is essential for PRL1-mediated cell growth and migration
  • play an important role in the regulation of neural function
  • PHF3 and/or PTP4A1 might play a functional role in alcohol dependence
  • PTP4A1, PTP4A2, PTP4A3 are key contributors to metastasis in several human cancers
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATF-7
  • P53, P21
  • cell & other
    REGULATION
    inhibited by sodium orthovanadate and pentamidine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS