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FLASH GENE
Symbol NIPSNAP1 contributors: mct - updated : 12 -11-201
HGNC name nipsnap homolog 1 (C. elegans)
HGNC id 7827
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2259 33.2 284 - 2012 2231198
10 - 1958 29 264 ubiquitously expressed in the neuronal tissues, especially in synaptic membrane and mitochondria of brain, expressed in the brain, spinal cord, liver, and kidney 2012 2231198
  • N-terminal truncated mature form of NIPSNAP1
  • PNOC interacted with the 29-kDa but not the 33-kDa NIPSNAP1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly Homo sapiens
    Nervousbrain   predominantly Homo sapiens
     spinal cord   predominantly Homo sapiens
    Urinarykidney   predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousadrenergic cell Homo sapiens
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • intracellular C-terminal region
  • HOMOLOGY
    interspecies homolog to C.elegans K02D10.1a
    homolog to Drosophila Nipsnap
    ortholog to murine Nipsnap1
    intraspecies homolog to highly homologous to NISNAP2
    Homologene
    FAMILY
  • NipSnap family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    text
  • localized in the postsynaptic density fraction of synapses
  • mature form of NIPSNAP1 was relatively concentrated in the synaptic membrane and mitochondrial fractions
  • basic FUNCTION
  • involved in the regulation of TRPV6 (Schoeber 2008)
  • regulates pain transmission mediated by PNOC
  • may be involved in a novel mechanism of pain transmission regulated by NST independent of a signal pathway acting through a G protein-coupled receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated protein inhibiting TRPV6 activity that possibly exerts its effect directly at the plasma membrane
  • is targeted to the mitochondria via its N-terminal targeting sequence, and interacts with mitochondrial chaperone translocase of the outer membrane 22
  • APP may affect mitochondrial function through a direct interaction with NIPSNAP1 as well as with other mitochondrial proteins
  • binds to the branched-chain alpha-keto acid (BCKA) dehydrogenase enzyme complex
  • interacts with the transient receptor potential vanilloid channel TRPV6, the amyloid precursor protein, and the branched-chain alpha-ketoacid dehydrogenase enzyme complex
  • NIPSNAP1 s a nocistatin-interacting protein, and interacting molecule of PNOC that plays a crucial role in pain transmission
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    of NF2, NIPSNAP1, UGT2B17, and LPIN2 genes during progression of a prostate epithelial cell line to a malignant metastatic state
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneouspain 
    novel therapeutic target for pathological pain
    ANIMAL & CELL MODELS
  • Nipsnap1-deficient mice abolished the inhibition of N/OFQ-evoked allodynia by PNOC