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FLASH GENE
Symbol SPAG4 contributors: - updated : 20-11-2006
HGNC name sperm associated antigen 4
HGNC id 11214
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   moderately
Endocrinepancreas   moderately
Hearing/Equilibriumearinnercochlea highly
Reproductivemale systemtestis  specific
Respiratorylung    
Urinarybladder   moderately
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage spermatid-specific
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) domain
  • an Unc84 (SUN) domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee SPAG4 (91.6 pc)
    homolog to rattus Spag4 (82.3 pc)
    Homologene
    FAMILY
    CATEGORY structural protein , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm
  • basic FUNCTION
  • involved in spermatids elongation
  • May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting specifically with the 27 kDa outer dense fiber protein ODF27 in elongation spermatid
  • interacting with ODF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential cancer marker
    Marker
    Therapy target
    ANIMAL & CELL MODELS