basic FUNCTION
| vitamin K-dependent protein isolated from human plasma, and acting as a cofactor for a serpin, called protein Z-dependent protease inhibitor (ZPI) |
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forming a Ca2 ion-dependent complex with activated F10 and a PROZ dependent protein inhibitor |
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involved in hemostasis by binding thrombin and promoting its association with phospholipid vesicles |
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being an important factor in the pathogenesis of ischemic stroke due to large-artery atherothromboembolism or an acute phase reactant |
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normal increase of protein Z during pregnancy may balance the increase of clotting factors to protect pregnant women from thrombosis |
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cofactor of PZ dependent inhibitor (ZPI) that inhibits activated coagulation factor X |
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role for protein Z deficiency in thrombotic diseases, including arterial thrombosis, pregnancy complications and venous thromboembolism |