basic FUNCTION
| acting as a transcription factor that regulates the mammalian circadian rhythm |
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overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators |
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is likely required for effective control of a food-entrainable oscillator |
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is not required for detection of or behavioral responses to a variety of acute or chronic metabolic deficits, but is more likely to be involved in effective synchronization of feeding behavior with scheduled food availability |
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with ARNTL were associated with reproduction and with seasonal variation |
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DNA-binding of NPAS2 and ARNTL to PER2 was decreased by sleep deprivation (SD), although SD is known to increase PER2 expression in the cortex (PMId: 22039518) |
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transcription factor that regulates mammalian circadian rhythms |
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its DNA-binding activity is specifically enhanced by NAD(P)H independently of NAD(P)(+) |
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essential role for NPAS2 in programming the peripheral circadian response and hepatic metabolism |
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controlled the circadian rhythm of NR0B2 expression by binding rhythmically to the NR0B2 promoter, which was enhanced by nicotinamide adenine dinucleotide |
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important role for the circadian protein, NPAS2, in the nucleus accumbens (NAc) in the regulation of dopamine receptor expression and drug reward |
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suprachiasmatic nucleus (SCN)-specific role for NPAS2 in the molecular circadian clock, and the core loops of SCN neuron and peripheral cell circadian clocks are fundamentally similar |
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NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus (SCN) |