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FLASH GENE
Symbol AP1S1 contributors: mct/npt - updated : 11-10-2017
HGNC name adaptor-related protein complex 1, sigma 1 subunit
HGNC id 559
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1297 18.6 158 - Takatsu, Folsch (1999)
- - 958 15.7 133 - Takatsu
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
 nerve   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to S cerevisiae,Yap17p
Homologene
FAMILY
  • adaptor complexes small subunits family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text form the AP-1 assembly protein complex located at the Golgi vesicle
    basic FUNCTION
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2 transporting ligand receptor complexes from transGolgi network to lysosome
  • playing a a critical role in development of the skin and spinal cord (Montpetit 2008)
  • regulate clathrin-coated vesicle assembly, protein cargo sorting, and vesicular trafficking between organelles in eukaryotic cells (Montpetit 2008)
  • AP1S1 complex mediates protein sorting between the trans-Golgi network and early endosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEDNIK
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in striatum and caudate from HD patients Mazarei 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS